![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g001.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA) Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/styles/content_image_medium/public/images/valenza_zamarripa_promo.jpg?itok=HRbtRBEw)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)
![Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry](https://ajp.psychiatryonline.org/cms/10.1176/ajp.155.4.470/asset/images/medium/a95f2.jpeg)
Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry
![Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway | Acta Pharmacologica Sinica Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway | Acta Pharmacologica Sinica](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Faps.2017.51/MediaObjects/41401_2018_Article_BFaps201751_Fig1_HTML.jpg)
Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway | Acta Pharmacologica Sinica
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g002.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging | ACS Chemical Neuroscience Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.8b00293/asset/images/large/cn-2018-00293f_0001.jpeg)
Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging | ACS Chemical Neuroscience
C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors | Journal of Medicinal
![Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling](https://www.science.org/cms/asset/35d59cc9-5e24-4990-b0eb-4fc248e3274c/9_ra117_f1.gif)
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling
![Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry](https://ajp.psychiatryonline.org/cms/10.1176/ajp.155.4.470/asset/images/medium/a95f3.jpeg)
Site of Opioid Action in the Human Brain: Mu and Kappa Agonists' Subjective and Cerebral Blood Flow Effects | American Journal of Psychiatry
![Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists](https://www.frontiersin.org/files/Articles/447554/fphar-10-00407-HTML/image_m/fphar-10-00407-g003.jpg)
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
![Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors - ScienceDirect Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0021925820553611-gr1.jpg)
Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors - ScienceDirect
![Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. - Abstract - Europe PMC Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. - Abstract - Europe PMC](https://europepmc.org/articles/PMC3378255/bin/cn-2011-00128x_0006.jpg)
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. - Abstract - Europe PMC
![Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling](https://www.science.org/cms/10.1126/scisignal.aai8441/asset/af19b0d1-3407-4f21-8f6d-9bcb1eddc0cd/assets/graphic/9_ra117_f2.jpeg)